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	Provedor de dados Anais da ABC (AABC) (1) BJMBR (1) Autor Castilho,Roger F. (1) Degasperi,Giovanna R. (1) Kowaltowski,A.J. (1) Vercesi,Anibal E. (1) Palavra-chave Free radicals (2) Mitochondrial permeability transition (2) Aging (1) Alternative oxidase (1) Cardioprotection (1) Cell death (1) Immune response (1) Lymphopenia (1) Spleen lymphocyte (1) Uncoupling proteins (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Alternative mitochondrial functions in cell physiopathology: beyond ATP production BJMBR Kowaltowski,A.J.. It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology. Tipo: Info:eu-repo/semantics/article Palavras-chave: Mitochondrial permeability transition; Uncoupling proteins; Alternative oxidase; Cardioprotection; Free radicals; Aging. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014 High susceptibility of activated lymphocytes to oxidative stress-induced cell death Anais da ABC (AABC) Degasperi,Giovanna R.; Castilho,Roger F.; Vercesi,Anibal E.. The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to tert-butyl hydroperoxide (t-BOOH)-induced necrotic cell death in vitro. The iron chelator and antioxidant deferoxamine, the intracellular Ca2+ chelator BAPTA, the L-type Ca2+ channel antagonist nifedipine or the mitochondrial permeability transition inhibitor cyclosporin A, but not the calcineurin inhibitor FK-506, render control and activated lymphocytes equally resistant to the toxic effects of t-BOOH. Incubation of activated lymphocytes in the presence of t-BOOH resulted in a cyclosporin A-sensitive decrease in mitochondrial membrane potential. These results indicate that the higher cytosolic Ca2+ level in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell death; Free radicals; Immune response; Lymphopenia; Mitochondrial permeability transition; Spleen lymphocyte. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100009 Registros recuperados: 2 Primeira ... 1 ... Última

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